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Structurally, the Leu33Pro substitution generates a Pro32Pro33 sequence, which may boost the pliability of integrin α
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In accordance with facts attained from Pro33 human samples, no modifications in plasma membrane integrin α
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three, amplified mobile adhesion, without any results on platelet aggregation in vitro. This mutation has dramatic outcomes on platelet size and it is present in Glanzmann thrombasthenia patients, suggesting that constitutive activation of α
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